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Therefore, we investigated the effects of JAK inhibition on factors that appeared to contribute to the reduced locomotor activity, such as pain, physical function, and fatigue, as important factors for QOL in RA patients.
Although there are few available reports, it is easy to imagine the correlation between physical function and spontaneous locomotor activity.
The primary outcomes were the WOMAC Osteoarthritis Index for pain, stiffness and physical function, the Aggregated Locomotor Function (ALF) test that evaluates each patient's physical function, the SF-36 quality of life health survey and the visual-analogue-scale (VAS) for pain.
Taken together, these findings indicate that inhibition of motor function by JAK inhibition arises as a result of suppression of joint destruction through the inhibition of joint inflammation, and that JAK inhibition does not ameliorate spontaneous locomotor activity through direct inhibition of physical function in AIA rats.
Parent et al [ 14] compared the responsiveness of 3 locomotor tests and 2 questionnaires using 4 different responsiveness statistics and recommended the 6MWT and the Physical Function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for assessment in the early recovery period after TKA.
At 2 months, the WOMAC physical function subscale and SF-36 physical function domain demonstrated significant improvement compared to patients' preoperative values whereas the locomotor tests were comparable to their preoperative values or significantly less (six-minute walk distance).
Its physical function is almost hidden.
Pain and physical function.
Physical functioning.
PF = Physical Functioning.
Physical functioning To assess physical functioning, three tests are administered.
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