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Similar to control flies, TDP-43CTF and TDP-43FFLL expressing flies showed a slight reduction in locomotion over time (Fig. 4D), which most likely reflects normal aging rather than detrimental effects of TDP-43 as seen in TDP-43WT and TDP-43A315T expressing flies.
The exacerbation of the decrease in locomotion over time is consistent with many studies showing that climbing ability decreases as a function of age [ 36- 38].
For this study, we used a modified hole board (mHB) task, which is a visuospatial task that allows for the simultaneous evaluation of different cognitive processes and other behavioural dimensions, such as avoidance behaviour, risk assessment, exploration, and locomotion over time (Ohl et al., 2003; Ohl et al., 2002; van der Kooij, Ohl, Arndt, Kavelaars, van Bel, Heijnen, 2010).
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Selected signs of changes in behaviour and mental status, sensation and locomotion observed over time are displayed in Figure 1, which also shows the findings in controls for comparison.
"People change over time.
Although these methods have proven well suited to detect gross changes in locomotor output, they are not well suited for analysis of trends in locomotion over longer time periods or the detection of subtle departures from control conditions.
The evaluation of treadmill locomotion, over-ground locomotion and footprint analysis were compared at 6 weeks post-injury, just before the terminal electrophysiological procedure.
To investigate this, MDA-MB-231 breast cancer cells were embedded in collagen matrix and cell locomotion was tracked over time.
The first dynamic includes a situation where the infrastructure is extended directly as the result of the consolidation of the physical signs of pedestrian locomotion on the environment over time.
The objective of this study was to quantify the effect of hoof trimming on cow behavior (ruminating time, activity, and locomotion score) and performance (milk yield) over time.
The pedestrian as a decision maker considers the locomotion process as a sequence of choices over time, in which the pedestrian decides where he will be at the next time step in the space around his present position [40].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com