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In the first experiment, naïve male ICR mice showed gradually increasing running wheel activity over three consecutive days after exposure to a running wheel, while mice without a running wheel showed gradually decreasing horizontal locomotion, consistent with running wheel activity being a positively motivated form of natural motor activity.
Finally, hts flies displayed impaired locomotion, consistent with a significant role for adducin/ hts in normal neuromotor function.
In the Y-maze spontaneous alternation test, Myk/+ mice showed increased exploratory locomotion, consistent with our previous observations in the hole-board test (Kirshenbaum, Clapcote et al., 2011).
Both serotonin signaling mutants and NSM ablation affect food-modulated locomotion, consistent with the idea that serotonin from NSM acts in this food-related response (Sawin et al., 2000).
A number of reports have convincingly shown that the loss of function of HSP-associated genes lead to major motor neuron defects, usually with impaired locomotion, consistent with the roles of spastin and other less common HSP genes that are involved in axonal transport (Blackstone, 2012).
Additionally, video recordings at 0-2 min and >2 hr after DPM activation at 31 32°C show that flies are immediately arousable by gentle tapping and have normal geotaxis and locomotion, consistent with DPM activation inducing a sleep state rather than paralysis or locomotor dysfunction (Video 1).
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A lamotrigine-induced decrease in locomotion is consistent with previous studies.
Tracks produced during continuous motion were indistinct from those produced during stop-start locomotion, which is consistent with experimental observations of birds walking on substrate, in which stopping mid-stance had no observable effect on surface track morphology (Falkingham, pers. Obs 2013).
showed some transient, statistically significant effects in drug treated R6/2 mice on body weight, locomotion and rearing, consistent with Chen et al's study, although the effects were not comparable to those published in effect size and duration [25].
Such spontaneous hyper-locomotion and paradoxical attenuation of hyper-locomotion with AMP is consistent with those observed in DAT-knockout mice [47].
The exacerbation of the decrease in locomotion over time is consistent with many studies showing that climbing ability decreases as a function of age [ 36- 38].
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