Cocaine increased locomotion and decreased grooming during treatment and on the conditioning test.
Levine JB, Leeder AD, Parekkadan B, Berdichevsky Y, Rauch SL, Smoller JW, Konradi C, Berthiaume F, Yarmush ML. Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats.
Both adenosine A1 receptor heterozygous mice and WT mice exposed to perinatal caffeine showed the tendency towards increased locomotion and decreased habituation (Figure 5).
Brain-directed overexpression of human soluble IL-1 receptor antagonist, hsIL-1ra, resulted in increased locomotion and decreased habituation, an anxiolytic effect, but did not influence motor performance [ 187].
We observed that Aβ43 was highly insoluble in vivo and that it led to severe toxic effects, both when constitutively expressed in the compound eye of the fly, leading to eye roughness, and when specifically induced in the adult nervous system, as measured by a progressive loss of photoreceptor neurons, impaired locomotion and decreased lifespan.
Using Drosophila transgenic models of amyloid pathology, we show that Aβ43 peptides are mainly insoluble and highly toxic in vivo, leading to the progressive loss of photoreceptor neurons, altered locomotion and decreased lifespan when expressed in the adult fly nervous system.
Repeated exposure to another commonly used behavioural test, the elevated maze, has been reported to result in a decrease in total locomotion and a decrease in the amount of time spent on aversive open sections of the maze (e.g. Cook et al., 2002; Dawson et al., 1994; Rodgers et al., 1996).
We found that as locomotion and rearing behaviour decreased, body licking increased gradually both within and between days, suggesting that the appearance of more complex and longer grooming sequences are part of a de-arousal inhibition system subserving novelty habituation.
In experiment 2, increased horizontal locomotion and food access, and decreased food intake, were observed for the initial 3 h after acute METH challenge.
In behavioral tests, the treated animals showed a dose dependent increase in catalepsy and decrease in locomotion.
