Rather, they are the tail ends of statistical distributions that reflect the shuffling of myriad, tiny genetic effects called quantitative-trait loci, whose true nature is not yet understood.
7302R-specific SNPs were identified for those loci whose nucleotides were similar to those in IR24, MH63, and SH527 but were different from that of 7302R.
Most phenotypes of evolutionary importance are quantitative traits, with continuous phenotypic variation in natural populations due to segregating alleles at multiple loci whose effects are sensitive to the environment.
Supergenes are groups of tightly linked loci whose variation is inherited as a single Mendelian locus and are a common genetic architecture for complex traits under balancing selection [1, 2, 3, 4, 5, 6, 7, 8].
There are even nonclassical loci whose functions are not related to immunity.
Dataset S1 lists the loci whose disruption caused a significant fitness change in each of the drugs tested.
Among them, we identified three human-specific Alu-RMI polymorphic loci whose minor allele frequencies were 0.6%, 1.3%, and 43%, respectively.
Much progress has been made in the identification of a network of loci whose expression is modulated by EWS/FLI1 and its congeners.
For those RRMI loci whose ancestral state was still ambiguous, despite both TSD and BLAT analyses, we experimentally confirmed the ancestral state using PCR assays.
Loci whose ηr was greater that the median ηr-median of ∼0.316 (0.1-min−1) were designated as efficient-replication loci or efficient loci.
Heatmaps displaying the data for loci whose disruptions were significant in individual drugs and classes of drugs are in Figures S4 S11.
