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Within seven out of these eight loci, we found that, on average, a substantially smaller number of variants was correlated (r2 > 0.5) with the most significant SNP in AA than in EA populations (16 versus 55).
Studying 1017 high-confidence ERα-bound loci, we found that genomic EREs are enriched for spacers composed of C(A/T G, suggesting that the spacer may influence receptor binding and transcriptional responses.
Although commercial kits now combine the five new STRs with existing core loci, we found the ESS-pentaplex we developed in-house performed better than both MiniFiler (comprising eight miniaturized STRs) and the NGM kit that includes the new STRs in a 15-marker multiplex.
From the analysis of regulatory loci we found evidence for a predominate role of the essential two-component system WalKR of S. aureus.
However, in our study population, where the majority of infections harbour many resistance-associated mutations in the dhfr and dhps loci, we found no evidence that parasites with three or more mutations in the dhfr or dhps genes have an additional transmission advantage compared to double mutations.
When we looked in detail at the 56 differentially-methylated loci, we found that the magnitude of DNA methylation changes observed in IUGR compared to controls is markedly less than many tissue-specific differences in methylation that we have previously observed ([44]; and data not shown).
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Assuming independent uniform distributions for the allele frequencies of two biallelic loci, we find that the mean maximum value of r2 is ∼0.43051, and that r2 can exceed a threshold of 4/5 in only ∼14.232% of the allele frequency space.
Assuming that the 'unknown' loci we find are false positives the procedure has 91% specificity and 45% sensitivity on the level of loci identified.
Substituting the average G from Symonds and Lloyd (2003) and our average μ across loci, we find that N e ≈ 2300.
When considering all loci we find that D. ananassae has slightly more synonymous polymorphism than D. melanogaster (Table 2), which suggest that the former has a larger Ne.
For two of the six loci, we find that the partition with strongest support is different from that assumed by Li et al. (2005), and for all six loci there are multiple partitions with reasonable support.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com