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While this information has laid an important foundation, it is important to investigate whether identified loci transfer across populations with different ancestral backgrounds [ 3] and whether novel variants could be identified as recently demonstrated in populations of East Asian and Indian backgrounds [ 4, 5].
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Furthermore, six associated loci transferred across all three population groups.
When we tested just the reported variants originally identified as associated with adult height in individuals of East Asian or European ancestry, only 8.3% of these loci transferred (p-values≤0.05 under an additive genetic model with directionally consistent effects) to our African American sample.
Collectively, a total of 38 loci (76%, 38/50 loci) transferred to the Chinese population with at least a nominal significance, highlighting a great deal of genetic homogeneity for type 2 diabetes between the European and Chinese populations.
Introduction of the mutated covR/S locus transferred the phenotypic appearance of the HH/LC variant to both the LH/HC and NEM316 strains, which resulted in increased hemolytic activity with increased pigmentation and decreased reaction in the CAMP testing.
Efficient transmission of circular plasmids in Streptomyces spp. proceeds by an uncharacterized mechanism that requires a cis-acting locus of transfer (clt) and often only a single plasmid-encoded protein.
Thus, we investigated whether the African American sample provided refined localization for the six loci that transferred across all three population groups (African Americans, East Asians, and Europeans).
Genome coordinates of extended human gene loci were transferred to the mouse genome sequence with UCSC Lift Genome Annotations tool (http://genome.brc.mcw.edu/cgi-bin/hgLiftOver).
We successfully used the shorter range of linkage disequilibrium in our African American sample to refine the localization of the six height loci that transferred across African American, East Asian, and European samples.
This conclusion is supported by the low number of loci encoding transferred genes [ 13, 61– 63].
Genomic coordinates of extended human gene loci were transferred to the mouse genome sequence using the UCSC Lift Genome Annotations tool (http://genome.ucsc.edu/cgi-bin/hgLiftOver).
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