Crack initiation loci together with force responses were compared to experimental observations.
Clustered, regularly interspaced, short, palindromic repeats (CRISPR) loci, together with their CRISPR-associated (Cas) proteins, provide bacteria and archaea with adaptive immunity against invasion by bacteriophages, plasmids, and other mobile genetic elements.
Waddington intended this diagram to make vivid the idea that the effect of a change at one genetic locus depends upon the states of all the other genetic loci, since it is all the loci together which determine the shape of the landscape.
Still these new loci together with the HLA-DQB1, -DQA1 and -DRB1 loci cannot explain the full effect of this region.
However, the analysis of all loci together (Figure 2 and Table S9) strongly supports the hypothesis that cancer reduces specialization of the tissues.
Taking the two loci together, our results thus suggest the −− genotype of the 23-bp locus might contribute a greater PRNP level compared to the −− of the 12-bp locus in animals with the −−/−− diplotype as we previously reported [23].
However, with more susceptibility loci being identified (e.g., by genome-wide association studies), and interaction effects among such loci together with other NPC risk factors taken into account, the prediction of NPC occurrence may become more accurate and clinically usable.
It would be surprising if more sequence data as provided by the three loci together would have resulted in weaker resolution or lower statistical support for various topologies than a single locus alone.
As shown by Centurion-Lara et al. [18], the tprI and tprC loci together with variable 5'- flanking regions of TP0171 tpp155) can differentiate between T. p. pallidum, T. p. pertenue, T. p. endemicum and the unclassified simian isolate.
For dataset C, which corresponds to human data for normal and tumor tissues grouped by chromosome, an individual analysis was performed for the loci in each chromosome followed by a complete analysis for all loci together.
Based on our data, and experience with a range of C. maenas microsatellite markers derived from geographically disparate populations, we anticipate that the combination of the current loci together with those of Tepolt et al. [26] and Darling et al. [13] will facilitate the application of an appropriately robust panel of informative polymorphic markers for population genetic studies.
