The main other loci that make up the shell phenotype are various forms of band-suppressing loci, all unlinked to the supergene, including the mid-band locus, U (unifasciata), and another that suppresses the first two bands, T (trifasciata).
Additionally, major-effect Quantitative Trait Loci that make mosquitoes resistant to Plasmodium have been identified in natural Anopheles populations [ 15].
Other loci that make smaller and/or more race-specific contributions to SCN resistance have also been identified throughout the soybean genome, but often a given locus was identified in only one study [ 10, 21- 25].
Whether there is some property of the fat2 locus that makes it particularly susceptible to sporadic mutagenesis or the mutation frequency is simply a function of the gene's large size remains to be determined.
There are extensive inverted repeats found throughout the C. elegans inx-22 inx-21 locus that make PCR assays in the region problematic and may account for the lack of fosmid or cosmid clones for the region.
Together, these data suggest that NeuroD4 becomes less prone to activation over time, likely through the initial transient repressor activity of REST followed by a histone modification that makes the locus more compact.
Additionally, the GSL loci have local rearrangements that make them nearly impossible to obtain accurate genotypic information using Illumina resequencing approaches and as such we have found that the data in the 1001 databases for these loci is inaccurate when we compare to direct BAC sequencing of the same accession.
Interestingly, V4 fulfils a variety of criteria that make it a promising locus for crowding.
However, the specificity of the pathological changes in the ENU-induced and BAC-induced mutant lines and the genetic interaction between the underlying genetic loci made that possibility unlikely.
To test this, we scanned the environment of Dact genes for genes that have four paralogs in all vertebrates, each associated with a particular Dact locus, making allowances for teleost genes that, after 3R were kept at the locus that since has shed the duplicated Dact gene.
