Sentence examples for loci partner from inspiring English sources

In addition to the Ig loci, partner genes of MYC rearrangements included FAM46C, KRAS and CCND1.

Given that the mechanism of upregulation of Ig loci partner oncogenes is through colocalization of active enhancer elements with the oncogene, we examined the remaining samples with rearrangements for the presence of enhancer elements.

How many partner loci are involved in incompatibilities?

Here, we have investigated the partner loci involved in rearrangements with 8q24, namely MYC.

The translocations at 8q24 results in overexpression of MYC due to the colocalization of active superenhancers in the partner loci.

The partner loci to MYC are also mostly related to myeloma pathogenesis or B-cell biology (Table 3).

The remaining samples had partner loci including XBP1, FAM46C, CCND1 and KRAS, which are important in B-cell maturation or myeloma pathogenesis.

8q24 breakpoints were identified in 21 (20%) samples with partner loci including IGH, IGK and IGL, which juxtapose the immunoglobulin (Ig) enhancers next to MYC in 8/23 samples.

Ig partner loci are recognized to upregulate expression of the target oncogene and have been shown to have clinical relevance as prognostic markers.

Differences between studies might reflect geographic variation in sterility alleles, but identification of domesticus-sterile X alleles only in generations beyond the F1 suggests that interactions with recessive autosomal partner loci are essential.

We predict that involvement of a sterility locus in multiple incompatibilities would reduce the influence of allele/genotype frequencies of any single partner locus on power.