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The backbone curves describe the loci of dynamic responses of a system when unforced and undamped, and are represented in the frequency amplitude projection.
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Haas et al proposed that these gene-poor repeat-rich loci are dynamic regions of the genome that underpin the evolutionary potential of P. infestans by promoting genome plasticity and enhancing genetic variation of effector genes.
The enormous antigen receptor loci in lymphocytes are a paradigm of dynamic nuclear organisation, which is integral to their need to move extensively in 3D space to achieve distal gene synapse for V(D J recombination and allelic exclusion.
Although genome-scale imaging has not been implemented with a library of sgRNA, visualization of specific genomic loci paves the way for further study of dynamic organization of the human genome.
Given the transcriptional complexity of some loci and the dynamic nature of transcript and locus annotations over time, it was important to capture the exact region spanning at least 80% of the 11 Affymetrix probes to minimize the variable expression patterns between the array and ISH.
The overwhelming majority of testosterone-affected loci showed dynamic CpG methylation patterns.
Beyond the specific example of the HoxA locus, dynamic changes of histone acetylation closely followed the dynamics of transcriptional changes (see Figures S5, S6 and S7 in Supporting Information S1 for example plots of HSPC-TF loci).
For the loci undergoing dynamic mutations, expansions begin when the length of simple DNA repeats exceeds a threshold of ~100 150 bases.
In addition, as PINK1 appears to influence mitochondrial membrane potential [ 1] and mitochondrial dysfunction is implicated in many age related diseases [ 22], studying the regulation of the PINK1 locus during dynamic in vivo modulation of mitochondrial function is likely to be relevant to human ageing.
It's the opposite of dynamic.
> Structure of dynamic VNS.
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