AID is a key enzyme for antibody diversification and due to its mutagenic activity outside immunoglobulin loci it is implicated in lymphomagenesis.
Before contemplating why it has been so difficult to map non-MHC loci, it is worth revisiting the MHC association, its discovery and subsequent dissection.
"This atelier was my genius loci, it felt like a small country mill," he said.
When assigning a gene name to such unmapped loci, it is essential to confirm that there is valid experimental evidence supporting the existence and function of the gene.
AID deamination is not exclusive to immunoglobulin loci; it can instigate DNA lesions in non-immunoglobulin genes and thus stringent checks are in place to constrain and restrict its activity.
For loci, it represents the 10th percentile rank for all GenCall scores for that locus.
Given the apparent overlap in susceptibility loci, it appears plausible that some of the genetic factors implicated in COPD might also be relevant in lung cancer [24] [29].
Because MLAS can simultaneously consider the genetic information of multiple loci, it is expected that MLAS were more powerful than SLAS in disease genes mapping.
Additionally, since changes at the ABO locus have been associated with changes at other 9q34 loci, it is likely that ABO alterations are not the leukemia causing event but rather a marker of other events occurring at this chromosomal region.
Because one gets multiple generations of gene spread from a single release (due to assortment of the multiple loci) it may be possible to reduce the number of releases that need to be performed.
While additional and independent replication studies are awaited for some of these loci, it is noteworthy that these genes support the disruption of neurotransmission networks of the brain as the underlying cause of MDD.
