Sentence examples for loci for prostate from inspiring English sources

Genome-wide association studies have discovered at least 30 susceptibility loci for prostate cancer.

There is a clear genetic component in prostate cancer susceptibility and several common low-risk genomic loci for prostate cancer susceptibility have been found but no high-penetrance genes have been identified [ 33, 34].

Taking this genome-wide association (GWA) approach, susceptibility loci for prostate cancer on chromosome 8q24 were recently identified, alleles which were also identified using family studies and linkage analysis (reviewed in [ 4]).

The chromosomal region of AMACR has been validated as a susceptible locus for prostate cancer, including hereditary prostate cancer [ 10, 11].

Nevertheless, we checked the chromosomal locations of the 76 established risk-associated loci (http://www.nature.com/icogs/primer/shared-susceptibility-loci-for-breast-prostate-and-ovarian-cancers/) and found that none were located within 10 kb of any of the 39 genes considered, with the exception of the FGFR2 locus.

Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identified.

Given the likelihood of locus heterogeneity for prostate cancer, stratification by clinical phenotype (including other cancers segregating in families and young age at diagnosis) may help to elucidate the prostate cancer susceptibility genes relevant to specific types of prostate cancer.

This analysis of 131 ACTANE families does not support the presence of a locus for a prostate cancer susceptibility gene at 1q42.2 43.

Analysis of men with a family history of the disease, however, indicates that this region may be a risk locus for familial prostate cancer.

To establish whether the 4q27 cytokine rich region is a locus for familial prostate cancer risk as suggested in this study, the association needs to be replicated in independent studies that include a larger number of men with a family history of the disease.

Therefore, the two loci confer independent risk for prostate cancer.