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This suggests that like the KRAB-ZNF subtype in frogs and other species, SCAN-ZNF loci expanded independently in reptilian lineages.
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The genome-wide association studies (GWAS) approach has dramatically increased the number of T2D susceptibility loci, expanding the list from five loci in 2007 to more than 60 loci in 2012.
As the number of risk loci expands it will become possible to test specific hypotheses based on implicated risk pathways, although the success of this approach will require better pathway annotation.
The rodent Oas1 locus expanded to a family of 12 genes, while both the canine and bovine clusters contain duplications of OASL and OAS1 genes, respectively [9], [10].
It is tempting to speculate that the function of IFNL has been replaced as the component genes of the Type I IFN locus expanded.
A 10-locus expanded panel derived from loci recently described for Irish zoonotic M. bovis strains (8 ) improved strain discrimination by producing different profiles for every isolate (Table 1).
The MHC class II region of the giant panda ultimately evolved into its current species-specific genomic structure after losing the entire DYA locus, expanding the DQ subregion, and extinguishing the duplicate DRB gene (Figure 7E).
The HD transgene is ubiquitously expressed in tissues of R6/1 mice [ 32], and CAG repeats at the HD locus expand upon repair of oxidative damage [ 8].
To identify consensus peroxisome proliferator response element (PPRE) motifs for PPARβ/δ in the binding region set, the loci associated with each peak loci were expanded to yield 400 bp regions for motif searching.
Rather than focus on known candidate loci, we expanded the search genome-wide to identify novel loci involved and also tested for global, non-specific effects of IUGR on cytosine methylation.
As DNA databases continue to grow and international cooperation increases, forensic STR loci have expanded to increase the discriminatory power and inter-database compatibility.
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