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Our analysis has identified thirteen distinct chromosomal loci encoding for sixteen NCX proteins in Arabidopsis and fifteen chromosomal loci encoding for twenty-two NCX proteins in rice; and hence are reported to undergo alternative splicing.
Our data suggest that deacetylation of critical lysine residues on histone H3 is an early event occurring at loci encoding for transcriptional inhibitors of myelin genes [10], [11], and is followed by decreased repressive me3K27H3 marks and increased activating me3K4H3 marks occurring at the loci encoding for myelin genes.
Common genetic variation in loci encoding for FGFR2 and MAP3K1 influences risk of breast cancer [2], [4], and these genes were previously found to be somatically mutated in diverse neoplasias including breast cancer [10], [11].
Variation in loci encoding for CDH1 and SMAD7 influences risk of colorectal cancer [16], [17] and, similarly, these genes were previously identified as inactivated or deregulated in tumors [18] [21].
This analysis suggested frequent influence on risk of genetic variation in loci encoding for "driver kinases" (i.e., kinases encoded by genes that showed higher somatic mutation rates than expected by chance and, therefore, whose deregulation may contribute to cancer development and/or progression).
Since two of the three chromosomes (7th and 9th chromosomes) putatively involved in anxiogenic processes contain loci encoding for either the GABAA receptor subunits (α5, β3, γ3) or for the 5-HT1B recepthe, thypothesissis of a biochemical correlate with anxiogenic behaviour patterns was tested.
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Some of these loci encode for subunits of potassium channels (KCNQ1, KCNE2, KCNJ2, and KCNH2 genes), and the remaining are yet unidentified.
While a comI locus has been predicted for B. subtilis spizizenii DSM15029 and B. subtilis natto BEST195, it remains to be elucidated whether these loci encode for a functional competence inhibitor.
Among the genes with known function, 33 loci encoded for protein kinases and, in particular, 22 for receptor-like kinases, of which 3 represented the receptor kinase LRK14 (Os01g0115600, Os01g0115600 and Os01g0117700) and other 3 the receptor kinase LRK10 (Os01g0117300, Os01g0117300 and Os01g0117500).
Among the known NBS-LRRs is the rust resistance Lr10 locus, encoding for CC-NBS-LRR receptors involved in wheat leaf rust resistance31.
In addition, and central to the understanding of cancer progression, common risk alleles showed differential influence according to ERα tumor status [12], and variation in the locus encoding for ERα, ESR1, also influences risk of breast cancer [13], [14].
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