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In one analysis which examined ten independent CAG-repeat-containing (non-CpG-containing) endogenous loci, differences in instability among the loci were noted (Brock et al. 1999).
Elevated divergence could be caused by differences in selection on individual loci, differences in mutation rate, or reduced susceptibility of these genomic regions to homogenization by ongoing gene flow.
Even if we classified as similar 1 case pair with only 2 loci differences according to VNTR (no RFLP type available: patient 4 in the Table), i.e., if we assumed that this difference was caused by evolution of the VNTR pattern or a processing error, the proportion of infections acquired outside the household still would be 77% (10/13).
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From the result, not only homologous and homoeologous loci difference were found, but also some evolutionary events could be inferred.
(C ) Copy number distribution of the 1% of loci with the highest siRNA:total RNA ratio compared with other loci; difference is significant by Wilcoxon Rank Sum test, p<2.2 × 10−16, loci scoring below noise threshold (0 2 category in B ) were removed.
A smaller proportion of isolates were more divergent, showing multiple locus differences between the MTs.
The 20 outbreak isolates showed allele differences at ≤8 loci on pairwise comparison, with a mean of 4 locus differences, across 1577 loci analyzed.
All taxa were represented for each of the 19 loci and missing data were only present within each individual locus (differences in sequence length).
Taken together these data suggest that the gapR STAR locus differences occurred in very early lineages of S. aureus and have been maintained at a level equal to that of CC in subsequent strains.
Thus, accruing data highlight the ability of neurones to decode information contained in amplitude, frequency, duration and locus differences in Ca2+ influx/mobilization [18 20,45], allowing CREB activity to be tightly regulated with respect to stimulus-specificity.
Distance matrices based on the number of locus differences were calculated among the 108 isolates and 20 previously published genomes [ 37] with the Genome Comparator tool and represented with NeighborNet graphs for the core loci (cgMLST) and the ribosomal protein (rMLST) genes [ 40].
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