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In S. pombe, these TFIIIC-bound loci cluster at the nuclear periphery [ 24].
Moreover, mating type loci cluster during silencing independently of peripheral positioning [ 22].
In S. cerevisiae and P. falciparum the silenced variation loci cluster in the nuclear periphery [ 8, 15, 59].
bAverage G + C content is presented for single locus or as an average value of the indicated loci cluster or operon.
Interestingly, porcine miRNAs highly expressed in these loci (cluster V) may target immune cell differentiation shown by pathway analysis, e.g via targeting the Notch and Wnt signaling.
This will retrieve information regarding cluster loci, cluster length, total piRNA within the cluster, prevalence of piRNA in plus/minus strand, %GC content in piRNA cluster and the corresponding motif.
Similar(54)
Interestingly, interactions between TADs are also highly cell-type-specific and often involve loci clustered around TAD boundaries.
Unsupervised hierarchical clustering using a set of most varying loci clustered the tumors into a Luminal A majority (82%) cluster, Basal-like/ErbB2+ majority (86%) cluster and a non-specific cluster with samples that were also inconclusive in their expression-based subtype correlations.
Similarly, six of the seven individual loci clustered with S. oralis strains; the other locus (sodA) clustered with S. mitis.
SIR complex relocalization was also observed when the yeast telomeres and silent mating-type loci clustering were disrupted.
Both colonic loci clustered together, they formed a superior group with the distal jejunum and ileum while duodenum and proximal jejunum clustered together (figure 3E).
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