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Deep re-sequencing showed that the frequencies of specific phases at contingency loci changed during passage.
Whole-body mRNA abundance of these males was compared to mRNA abundance of males not exposed to females, using whole-genome microarrays, and 43 loci changed expression consistently between the two categories.
For all the 8 STs observed in B. abortus strains from 1970-1980s, 6 of the 9 loci changed.
The major alleles of the wild population in these outlier loci changed to minor alleles in the populations of landrace or modern cultivars.
(53) As non-tumor liver tissue is more similar to normal liver tissue than the HCC tissue, the DNA methylation status of the affected loci changed gradually with the transition from normal liver to non-tumor liver tissue and further to a malignant phenotype of HCC.
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Moreover, during B cell development Ig loci change their nuclear positioning [ 3].
For example, while H3K27me3 at the HOX loci changes drastically from ESC to HSPC and beyond (Additional file 1: Figure S3), most of the genes in these clusters retained H3K4me3 in the promoter regions (DATA NOT SHOWN).
As the patterns in DNA methylation of these loci change over age, it may explain the polygenic, complex, and subtle features that are observed in the development of obesity and T2D and their subsequent course.
These results illustrated that the ATX1 level at the WRKY70 gene locus changed in response to dehydration and depended on the presence of a functional AtMTM1.
On the evolutional timescale, it appears that the major changes on the DAT sequence occur after a chromosomal translocation event during which the SLC6A3 locus changed its genomic position from chromosome13 in rodents to chromosome5 in primates.
In the presence of epistasis, the effect of one locus changes the effect of another locus on the phenotype.
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CEO of Professional Science Editing for Scientists @ prosciediting.com