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Therefore, identifying the locations of copy number changes is a key step in the analysis of DNA copy number data.
DNAcopy formulates the problem of copy-number variation (CNV) analysis as a change-point detection problem, whereby change-points correspond to the genomic locations of copy number transitions.
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This approach has the result of ignoring genes for whom the breakpoint, i.e. the specific location of copy number change, is found within the coding regions.
NGS-based CNV detection utilizes high-coverage WGS data for unbiased detection of CNVs at much higher resolution than has been available to date, providing information about CNV breakpoints and the location of copy number gains [ 105, 106].
Our results provide evidence for the location of copies on X and Y chromosomes, and the absence of this gene on autosomes.
The most frequent form of self-plagiarism in APPS submissions is text recycling, which depending on the extent and location of copied text, has consequences ranging from authors being required to rewrite duplicated text or add citations, to automatic rejection of a manuscript without review.
The mixture was fitted using an EM algorithm [ 11] with initial parameters calculated from the clusters returned by k-means with centers set to the eight expected locations of the copy number groups.
These gaps were probably due to the lack of long sequencing reads that can resolve the locations of four copies of the ycf2 fragment during sequence assembly.
We divided our data into three groups (referred to as "core classes") according to presence, sequence identity, and relative locations of additional copies of indel sequence in the neighboring (± 5 kb) region.
Breakpoint locations and calling of copy number levels (gain, unchanged, heterozygous loss, and homozygous loss) are provided as additional file 1 and 2.
An article on Tuesday about a memorial service for Sunando Sen, who was pushed to his death in front of a subway train, misidentified the location of a copy center where he had worked.
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