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One possibility is to infer the location or function of genes that are over- or under-expressed [ 8, 12].
Usually this is done in a supervised manner, such that SNPs related by location or function, for example, are tested simultaneously.
From databases and experimental literature we collected 62 yeast and 51 rat proteins with a peroxisomal location or function (Table 1).
In all cases, use of several programs based on different rationales is required to improve the quality of the prediction of sub-cellular location or function of a protein.
Finally, a proportion of protein cysteine residues will undergo reversible modifications that can alter protein activity, location, or function and thereby coordinate the transmission of redox signals (D'Autréaux and Toledano, 2007; Sobotta et al., 2015).
To investigate which probe types contribute most to the difference in methylation between cases and controls in the EPIC population, we stratified the association between epigenome-wide methylation and breast cancer risk for different groups of probes based on location or function (Table 3).
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More importantly, these databases solely focus on CHD-related genes, such as sequences, chromosome locations or functions, without considering the critical genes genes relationships that clearly play an important role in their cellular activities and pathological progression of CHD.
Gene sets corresponding to 1625 biologically defined gene sets representing pathways, locations, or functions were derived from the following public databases: Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO), Biocarta, and Reactome [ 29– 31, 70].
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They are not unified by location or time or function.
These results suggest that other genes besides peel-1 might weakly contribute to the incompatibility at that genomic location or that the function of peel-1 is not completely abrogated by the transposon insertion.
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