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The location of mutations in the amino acid and nucleotide sequences of TEAS are presented.
For example, although there are differences between mice and humans, new models are able to more accurately model sporadic human cancers by specifically controlling timing and location of mutations, even within single cells.
But pleiotropic consequences may be mitigated by the precise type and location of mutations.
Our results are the first indication that patients with low iFLC, which may appear to be at a lower risk for advanced disease, may be susceptible for amyloid formation because of the location of mutations in their proteins.
That we find no significant correlation between the location of mutations and predicted CTL epitopes might be due to differences between CTL epitopes in the strength of the immune selection pressure imposed on them, which would reduce the detection power of our method of testing for selection pressure.
Model 5 explained a greater percentage of the variance in FSIQ than the other alternative two group models based on assignment of mutations to DMD isoforms, and also accounted for more of the variance than 2 group models based on the physical location of mutations proximal of exon 30 (F = 10.44; p = 0.002) or exon 45 (F = 12.82; p = 0.0007).
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Additionally this fragmentation is potentiated to support widely range of fragment ions which can cover the location of mutation.
Therefore, secondary structure composition does not seem to affect the location of mutation clusters.
APP mutations are indicated as the location of mutation in APP770.
The location of mutation in LCT does not seem to affect the severity of the disease.
HR strategy for gene correction requires double-strand breaks (DSBs) at the precise location of mutation.
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