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The fact that the average number of polymorphic sites in the proximal-loci group (151.5) is 18% more than that in the subtelomeric-loci group (128), indicates that proximally located loci seem less homogenized than the subtelomerically located loci.
Two other groups have previously reported parent-of-origin linkage with autism for closely located loci on chromosome 7; one was a paternal contribution in the region 7q31.33-7q34 [19], the other showed a paternally derived locus more proximally located on 7q22.1-7q22.2 and a maternally derived locus on 7q32.1-7q32.2 [20].
Multiple mechanisms can mediate miR dysregulations in human cancers, including chromosomal gains or losses [ 7], mutations of miR located loci [ 8], or epigenetic aberrations [ 8].
Comparing values from sets of sequentially located loci to the matching sets from the resampled distribution can be used to superimpose the expected percentiles from the resampled distributions to real ones.
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This consensus map was useful in locating loci associated with various traits of agronomic importance.
In this study, both P values and FDR adjusted P values showed similar effect in locating loci if referring to the peaks of significance above –log(P) ≥6 or –log(FDR adjusted P) ≥3 (Additional file 6: Figure S2A).
We searched for GWAS-traits enriched for eSNPs located in loci of pseudogene and loci of ncRNAs.
We found 17 GWAS-traits nominally enriched for eSNPs located in loci of ncRNAs (Supplementary Material, Table S8) and 14 GWAS-traits nominally enriched for eSNPs located in loci of pseudogenes (Supplementary Material, Table S9).
Genetic mapping using microsatellite markers has located two loci associated with DDT resistance in A. gambiae [ 25].
I'd pondered this question for years, and although I'd never deduced any logic for my fear, I had located its locus.
This intron was 2,401 bp in full length and AluJb-641 was located at locus 192.
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