Although the number of samples was small and the quality of RNAs from refractory cancers due to sampling at autopsy was problematic, it is clear from the present transfection study that down-regulated expression of Lsm1 gene located at 8p11.2 is intimately involved in invasive and metastatic ability of human prostate cancers.
Special pressure sensors called baroreceptors can detect arterial blood pressure; they are located in the carotid sinus, which is intimately associated with each carotid artery high in the neck, and in a group of specialized cells in the left atrium of the heart.
|} The pituitary gland is located at the base of the brain, and intimately connected with the hypothalamus.
In P. falciparum P41 is intimately associated with GPI-anchored proteins that are located to the surface of merozoites (i.e. in lipid rafts).
In P450BM3, a highly conserved threonine residue (Thr268), which is located within the I-helix in close proximity of the heme, is intimately involved in the protonation/stabilization of heme-bound intermediates (e.g., hydroperoxo iron species) during the catalytic cycle of P450s as monooxygenases.
Extending these findings to the hippocampus, we report a reduction of total dendritic complexity of the neurons located in the CA1 and DG regions, suggesting that these changes might be intimately related to dysfunctions in the memory and learning processes of mice chronically infected with T. gondii.
The gap junction, located at the cell membrane, is basically comprised with different Cx (connexin) proteins, which are intimately correlated with diverse cell functions [ 6, 7].
These results are in line with early data from Schizosaccharomyces pombe, where both classical HDACs and sirtuins act intimately together and are required for efficient silencing of genes that are often located in subtelomeric regions (Hansen et al., 2005; Wiren et al., 2005).
In fact, some process philosophers (e.g., Whitehead) argue that the traditional notion of substance (a time-invariant, necessarily located particular) precisely lacks any experiential grounding, while process philosophy can draw on the experience we are most intimately familiar with, namely, the way in which we experience ourselves.
