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Comparing given promoter sequences we can observe that in the case of the IκBα gene in human, the groups of TFBS found are located in the distant region of the promoter whereas in other studied species, NF-κB family-related TFBS are located in the proximal region of the promoter, and mostly conserved.
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OsDCL2b (in Bin1205) was located in the consecutive distant-sQTL hotspots (Bin1199 Bin1210) on chromosome 9, which regulated the expression variation of 3759 s-traits.
OsRDR2 (in Bin636 and Bin637) was located in the consecutive distant-sQTL hotspots (Bin632 Bin637) on chromosome 4 regulating 1416 s-traits.
Patients with subacute local brain injury, either ischemic stroke or brain tumour, also exhibited 11C-DAG spots located in the associative areas distant from the lesion between 2 weeks and 1 month after injury; one of the possible features of neural recovery in the intact brain related to PI metabolism in PET imaging [102].
Other studies using ChIPseq or ChIP on chip to isolate binding sites for nuclear receptors also showed that only approximately 10% of binding sites are located inside of 5 kb from the TSS, whereas the majority of binding sites were located in the intron and/or far distant region [30], [31], [32], [33], [34], [35].
Metastases were located in the peritoneum (n=17), omentum (n=25), distant lymph nodes (n=6), and uterus (n=2).
The distribution of p53 mutations was patchy, with most being located in the lining layer, an area distant from oxygenating vasculature and bathed in oxidant-rich synovial fluid.
Sound recordings were achieved in two Tanzanian coastal forests located in the Rufiji valley (Rufiji District) and distant of 50 km.
Although they also show that the first CpG island located in the first exon is unmethylated, other distant regulatory regions could be altered as reported for the IGF2/H19 system.
One out of thirty-seven patients had a distant relapse located in the soft tissue (left side lower lateral ribs) and is in persistent second CR (Table 3).
The existence of a second GS2 gene in the genome of M. truncatula, located in the same chromosome and not too distant from the first gene suggests a recent duplication event.
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