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Trp93 is highly conserved among the Tob/BTG family and is located in the Box B motif (Fig. S1).
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The 1653 position is located in the box alpha domain that might change the stimulatory effect on BCP.
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The relay is located in the derivation box that feeds the destination node.
The relay is located in the derivation box that feeds the source node.
The aromatic side chain of the C-terminal Phe−1 is located in the "aromatic box" formed by Trp2185.39, His207ECL2, Tyr1894.61, and Trp209ECL2.
P209 and S399 residues are located in the conserved box 4 and 7, respectively, in close proximity to invariant residues that are conserved in all aminotransferases (Figure 3A; [12]).
Therefore, some molecules in the same cluster in the correlation analysis may not be located in the same box in a given coexpression analysis (heat map).
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