Since this lytic activity cannot be connected with a neoplastic nature of the disease, one can reasonably assume that histiocytosis X cells induce bone resorption in eosinophilic granuloma through their ability to secrete locally tissue-lytic factors such as interleukins and prostaglandins [53].
Tissue sections containing calcifications, and the locally surrounding tissue were imaged using a pixel size of 6.25 μm and a 4 cm−1 spectral resolution with 64 scans per pixel.
Extensive pulp defects of the thumb, with the exposure of tendon or bone, are challenging reconstructive problems because of the lack of locally available tissue.
Several combination device strategies load CGM sensors with drug payloads that release locally to tissue sites to mitigate FBR-mediated sensor failure.
However, to the human host, cytoadherence and consequent accumulation of masses of late stage infected cells in the capillaries may obstruct microcirculatory blood flow, leading to metabolic dysfunction and locally diminished tissue perfusion and finally organ failure.
Generally speaking, the nonlinear susceptibility formalism is relevant for locally uniform tissue structures.
Locally, both tissue specific stem cells and ubiquitous mesenchymal and endothelial progenitors have been implicated in the development of the cellular effectors of repair: fibrotic matrix producing cells, adipocytes and osteocytes.
Recently, Holzapfel and Ogden (2009) proposed a structure-based constitutive model of ventricular myocardium that accounts for the locally orthotropic tissue microstructure by expressing the strain-energy function using fibre-based material invariants.
Ineffective DNA clearance might be an aggravating factor at end-stage kidney disease because the increased presence of free nucleic acids might trigger innate sensors locally in tissue (Fenton et al., 2009).
However, renin-angiotensin-aldosterone production also occurs locally in tissues such as the heart, blood vessels, and kidneys, and these local systems may become progressively and chronically activated (Remme 1999).
