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A complex network of mechanisms involving induction of lineage instructive transcription factors, installation or removal of histone modifications and changes in the DNA methylation pattern locally orchestrate the three-dimensional chromatin structure and determine cell fate.
Apart from T cells, dendritic cells are abundantly present at the sites of inflammation and locally orchestrate the immune response.
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It was seen as an effort to prove that the insurgency in eastern Ukraine was rooted locally, not orchestrated by Moscow.
Plant responses to many biotic and abiotic stresses are orchestrated locally and systemically by signaling molecules known as jasmonates (JAs), which are derived from linolenic acid via the octadecanoid pathway [ 1, 2].
The factors and mechanisms regulating the mobilization of neutrophils from the bone marrow during inflammation are, however, unknown Chemokines are generated locally at sites of inflammation, and orchestrate the local recruitment of neutrophils from the blood into tissues by promoting neutrophil adhesion to the endothelium and transmigration into tissues.
Systemic and locally produced steroids and growth factors orchestrate the outgrowth and differentiation of the epithelium throughout the gland during puberty, followed by additional rounds of proliferation and differentiation during pregnancy, lactation, and involution [ 1, 3].
Light orchestrated pop songs, known locally as schlager music, are so prevalent that the festival is sometimes referred to as Schlagerfestivalen ("The schlager festival") by the Swedish media.
This way, activated PKA can act locally and directly on its substrates, thereby orchestrating substrate specificity.
The problems that Main Street faces could be solved locally, without recourse to the financial markets that Wall Street and other financial centers orchestrate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com