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Virtually all the localizing split 8-mers with an insert length of 5-bps or more contain the CG dinucleotide.
The 20 most localizing split 8-mers with insert length of 0-bps, 2-bps, 4-bps, and 5-bps to 30-bps are presented in Table S1.
The most localizing split 8-mer sequences with an insert length of 1-bps and 2-bps both represent the CRE motif, suggesting that the CRE is 10-bps long (GTGACGTCAC).
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We've spent a lot of time on localizing localize.
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To identify split 8-mers that localize in proximal promoters at only a precise insert length, the max LF for all split 8-mers with insert lengths from 0-bps to 30-bps (X4-N1-30-X4) were determined and compared with the ratio of max LF to the second highest LF.
We extended our previous work with split 8-mers in human promoters (Vinson et al. 2011) by evaluating whether the split 8-mers that localize in promoters have a preferred distance between the two 4-mers.
Seed investment in earlier rounds is split between Singapore and localized offices in places such as Vietnam and Indonesia. .
This article examines the split 8-mers that localize in human promoters.
A close to 1 ratio of max LF to the second highest LF indicates localization of split 8-mers at various insert lengths, whereas a ratio with higher values is indicative of split 8-mers that are localized at a precise insert length.
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