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However, when human neutrophils were "stalled" by simultaneously blocking actin and myosin dynamics, they maintained the gradient of responsiveness to chemoattractant and also displayed noise-driven PIP3 flashes on the basal membrane, localized toward the front.
From syn-orogenic to post-orogenic exhumation, deformation progressively localized toward the base of the CBU, along large-scale ductile shear zones, allowing the preservation of earlier HP-LT structures and HP-LT metamorphic parageneses.
After a regional switch from compression to extension, deformation localized toward the ETSZ and other internal shear zones such as the newly described Saleccia Shear Zone, as shown by strain intensity mapping in the eastern granitic protoliths.
However, Fgf3 staining was more localized toward the center of the retina, while Sfrp2 staining extended more peripherally (compare Figure 4B and 4E).
In human lymphocyte nuclei, which exhibit an spherical shape, chromosome 19 is consistently localized toward the nuclear center without any detectable attachment to the nuclear envelope, whereas chromosome 18 is positioned close to the nuclear border [22], and this nuclear arrangement was reported to be highly conserved [23].
In these cells centrosomes are present but organize fewer microtubules while most of the cellular microtubules are non-centrosomal and the minus ends are localized toward the plasma membrane without γ-tubulin anchorage.
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The profile for all introns had regions of methylation localizing toward the intron/exon junctions (Fig. 6a).
The analyses yielded mean values for θ of 126° ± 7° /SEM/ and 23° ± 3°, and the BA values of −0.32 ± 0.05 /SEM/ and 0.51 ± 0.04 for uncompacted (n = 49) and compacted (n = 65) embryos, respectively (t test, p < 0.001; Figures 1B 1D), indicating that Cdx2 transcripts localize toward the apical region upon compaction.
Rhodamine, the most hydrophilic compound investigated, was localized strongly toward the microsphere surface, while the much more hydrophobic compound, piroxicam, distributed more evenly.
The chromatin becomes asymmetrically localized and concentrated toward one side of the nucleus, generating polarity that imparts a distinctive crescent-shaped appearance to the Hoechst-stained chromatin in transition zone nuclei that is readily evident, even in low magnification images (Fig. 3A).
And when localized and misdirected toward xenophobia, nationalism or economic survival (the former two usually obfuscations of the ever-present reality of the latter) the results are human tragedies of ignorance.
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