Sentence examples for localized therapy from inspiring English sources

To demonstrate the effect of 5AR inhibitors prior to localized therapy, Andriole and colleagues (2004) randomized 46 men with clinically localized prostate cancer to either dutasteride or placebo for 6 to 10 weeks prior to radical prostatectomy (Andriole et al 2004).

While surgical extirpation or radiation therapy are commonly recommended for the treatment of localized prostate cancer, hormonal therapy is most frequently used for locally advanced disease, biochemical recurrence after localized therapy, and metastatic disease.

Tumor cell growth inhibition through cell-cycle arrest may be a significant mechanism of the formation of locally confined slow-growing oligometastases that are amenable to treatment with localized therapy or resection.> -wrap-foot> Functhats thareare up-regulated by a micro-RNA are italicized Oligometastasis is a unique phenotype observed in some cases of metastatic cancer.

Hogan and his collaborators have put together a robotic gym that helps deliver localized therapy to various limbs and joints throughout the body.

Finally, a discussion of the physiological barriers to localized therapy (i.e. drug penetration, transport), technical hurdles, and future outlook of the field is presented.

Recognition of cIALCLs as a distinct clinicopathologic entity, and in particular their distinction from aggressive, usually EBV cIT/NKLs, may be possible on the basis of a combination of clinicopathologic criteria, allowing for localized therapy in a subset of patients.

It then reviews the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms, and thereby provide targeted or sustained drug delivery for localized therapies in mucosal tissues.

These localized therapies exist in a variety of form factors designed to facilitate the delivery of drug directly to the site of disease in a controlled manner, sparing off-target tissue toxicities.

Localized therapies, including surgery, whole-brain radiation, and stereotactic radiosurgery, are indicated for the treatment of CNS metastases across breast cancer subtypes, but are associated with high rates of intracranial progression [ 10– 10].

This finding, coupled with our increasing ability to create highly specific molecular carriers for radionuclide therapy, suggests a bright future for therapy with alpha emitters and other highly localized radionuclide therapy agents.

Like in bladder cancer management, localized adjuvant therapy has been advocated to reduce the risk of disease recurrence or progression.