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Contact dermatitis, localized redness and swelling of the skin, together with the formation of vesicles (blisters) in more severe cases, caused by skin contact with irritating chemical substances.
Associated adverse effects include anaphylactoid reactions (most probably related to too rapid or too low temperature administration), the formation of inhibitory antibodies, localized redness at the injection site, and general reactions such as fever, chills, and headaches.
In two of the studies, localized redness occurred around the injection site in all 28 patients, and in one of these patients the reaction around the injection was extensive (Lynch et al., 1996, 2000; Table 3).
Redness of oral mucosa was graded using the Eilers Oral Assessment Guide (negative: no redness on the oral mucosa; slight: localized redness areas without ulcerations; moderate: redness on the whole oral mucosa without ulcerations; severe: ulcerations with or without bleeding) [ 16].
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Some clinical manifestations of acute CNI are localized pruritus, redness, heat, and edema (Herbert and Holzer 2002; Roosterman et al., 2006; Teresiak-Mikołajczak et al., 2013).
Localized skin redness and itching at the site of infection were reported in the hookworm group, particularly between 1 and 21 days after infection.
These criteria included one or more of the following self-reported conditions: 1) purulent wound secretion; 2) pain or tenderness, localized swelling, redness, or heat at the surgical site.
Medical problems linked to breastfeeding comprise a continuous spectrum of pathologic states ranging from breast engorgement due to reduced milk flow (stasis) to clinical mastitis (an inflammatory process in the breast producing localized tenderness, redness, and heat, together with systematic reactions of fever, malaise) [ 14], which may extend to breast abscess [ 13].
The swelling and redness was localized to the same areas on the dorsum of the hand.
Both localized skin itching and redness were significantly higher in the hookworm group compared with placebo group, particularly during the high risk period [difference in medians for mean daily score 1.02 (P=0.001) and 1.12 (P<0.001), respectively; Table 4 and Fig. 2].
Localization is finally localized.
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