Even if temporal patterns are localized, a large proportion of network nodes may be active in response to a given input, albeit with distinct temporal dynamics.
Note that even if the eigenvectors are localized, a large proportion of network nodes could respond to a given input, but they would do so with disparate temporal dynamics.
Twenty-two percent of the genes in Cluster 2 are associated with the GO term cellular response to stimulus (n = 14) and a significant proportion localized to the lysosome (n = 6), including lgmn, ctsk, ctss, asah, atp6v0d1, and neu1.
Subsequently, the amount of protein produced and the proportion actually localized within the plasma membrane, was quantified using YFP-constructs and flow cytometry analysis in non-permeabilized and permeabilized cells.
There are many density estimation methods including k-nearest-neighbour methods, histogram methods and kernel methods, which are localized with only a small proportion of all points which contribute most to the density estimation of a given point [18].
These results indicate that the proportion of GANP localized to NPCs interacts either directly or indirectly with a subset of nucleoporins.
These findings suggest that the intracellular distribution of cardiac Cx43 may be altered by short-term pacing with a reduced proportion that is localized to the sarcolemma.
Thus, although VAPB is not exclusively localized to MAM, a significant proportion is present in this ER compartment and modulating PTPIP51 expression influences the amount of VAPB that is associated with mitochondria.
A low proportion of SCVs localized with VCP, as was also the case for SptP, indicating that interactions with the SCV are likely transient or, alternatively, that the site of action of VCP is not the SCV itself.
If Atx3 is a nuclear shuttling protein, interfering with its putative nuclear export would be expected to modify Atx3 subcellular localization by increasing the proportion of the protein localized in the nucleus.
