This small retrospective series represents the largest series to date specifically reporting localized RT outcomes for CD30+ LPD using a multifractionated and single-fraction approach.
Localized disease has favorable outcome with an overall survival rate for stage 1 disease of 75-90%.
Tumor-harboring status of the SLN is the strongest predictor of outcome for clinically localized primary cutaneous melanoma patients.
Despite recent improvements in therapeutic strategies and outcomes for clinically localized disease overall survival in patients with the majority of metastatic and recurrent genitourinary malignancies remains relatively unchanged.
This in turn might also influence the outcome of the disease course (localized versus generalized WG).
Because such a response is undifferentiated, the outcome is systemic rather than localized.
In addition, the occasional PAs that show leptomeningeal dissemination (not just localized leptomeningeal involvement alone) have a poorer outcome [ 14].
Chromosome 8q gain is known to be associated with poor outcome in patients with clinically localized prostate cancer [ 41, 42] and node-negative breast cancer [ 30, 31].
46 Ulceration is an integral component of the AJCC/UICC staging system and an independent predictor of outcome in patients with clinically localized primary cutaneous melanoma.
Histologic parameters of the primary tumor are the strongest predictors of outcome in patients with clinically localized primary melanoma and strongly influence the next stages of management.
