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Together, these observations suggest that interactions with radial glial scaffold and localized migration within the expanding cerebral wall may play essential roles in the guidance and placement of interneurons in the developing cerebral cortex.
Thus, we believed the Fairview stand would be colonized via localized migration, providing a signal of fine-scale spatial genetic structure.
Interestingly, numbers of CD34+ cells were similar in muscles from different anatomic regions (5.3±0.4/HPF vs. 2.2±0.3/HPF in adductor muscle, P<0.001), suggesting a widespread recruitment of progenitor cells rather than a localized migration (Figure 9C).
The flipside of localized migration is, however, that the spread of infection across the population as a whole proceeds more slowly and more generations are needed to reach the equilibrium prevalence in the population as a whole (data not shown).
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Views from above on the apical cell side in 3D images show in detail transcellular PMN migration, in which the centrally localized PMN migrates distal to the TJ.
Since PLSs grow on retraction fibers, and retraction fibers are localized along the migration path of cells, we speculated that formation of PLSs is migration-dependent.
In active movement cells, uPAR is localized at the migration front thereby focusing uPA activity where proteolysis is required.
RhoA and Rac1 have a mutually antagonistic relationship where activated Rac1 is localized to the migration front, promoting actin polymerization and driving protrusions, and activated RhoA is localized to the trailing edge, driving contraction.
We consider similar factors as Kaufmann (2007) and use the principal component analysis approach to construct the IMI as follows: Y={a}_1{X}_1+{a}_2{X}_2+{a}_3{X}_3+{a}_4{X}_4 (3)where Y is the constructed IMI, a i are the principal component coefficients, and X i is a set of variables including the length of migration, remittance transfers, localized physical assets, and localized social capital.
Further studying the effect of elevated and ectopically localized Reelin protein on migration neurons may help to better understand the mechanism of both Lis1 and Reelin in cortical neuronal migration.
In the native ECM, the cells can migrate either via localized matrix degradation by matrix metalloproteinases (proteolytic migration) or via local deformation of the ECM (nonproteolytic, or amoeboid migration).
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