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Localized involvement of parts of the bowel with fibrosis has been reported in the past, and it has been suggested that it could be more common than previously recognized [ 13, 14].
Small lytic lesions of the cortex, localized involvement of the soft tissues and thin peripheral periosteal reaction can be seen; lesions with slow evolution which displace and expand the cortex peripherally can be distinguished from more aggressive lesions which cross the cortex.
IgG4-related sialadenitis more often affects males and manifests as diffuse gland swelling rather than localized involvement of the parotid glands, the IgG4 is elevated, the presence of SS-A antibodies is rare, and histologically the plasma cells infiltrating the glands express IgG4 and the fibrosis is more pronounced as in Sjögren's syndrome and storiform.
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Localized bone involvement is very rare (8 ).
In addition, the occasional PAs that show leptomeningeal dissemination (not just localized leptomeningeal involvement alone) have a poorer outcome [ 14].
In RA, localized bone involvement in the hands can be measured by digital X-ray radiogrammetry (DXR), which gives an estimate of cortical hand BMD in the metacarpals two to four.
The atrophy profile of C9ORF72 mutation cases contrasts both with the relatively localized temporal lobe involvement associated with MAPT mutation cases and the strongly asymmetric profile in GRN cases.
Enlarged contralateral lymph nodes must be negative microscopically Stage 3 Unresectable unilateral tumor infiltrating across the midline, with or without regional lymph node involvement; or localized unilateral tumor with contralateral regional lymph node involvement; or midline tumor with bilateral extension by infiltration (unresectable) or by lymph node involvement.
The current management of newly diagnosed ENKL patients was mainly based on the involvement sites (localized or disseminated disease).
Furthermore, the Crocus sativus and Arabidopsis CCD4s, have been shown to reside in plastids, where their substrates are localized, suggesting a direct involvement in volatile formation [ 19].
By comparison, in the rapamycin-treated group only 8 of the 31 (25.8%) lymph nodes with metastatic tumor showed extensive lymph node involvement, while 74.2% of the metastatic lymph nodes had only minimal tumor involvement that was localized to the subcapsular sinuses (p = 0.0001; Fisher exact test of independence; Figure 1E-I and Table 1).
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CEO of Professional Science Editing for Scientists @ prosciediting.com