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The methodology is designed to be flexible and intuitive, and scalable from small, localized functionality to large complex dynamic systems.
Taking advantage of chemical diversity and biological activities of this short peptide sequence, in this study, Pluronic F127 nanomicelles engineered with nuclear localized functionality were successfully developed for intracellular drug delivery.
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This is a desirable property considering the highly localized functionalities of genes as they relate to specific phenotypic signatures.
In surgical treatment, the intraoperative detection of tissues is becoming important in order to localize malignant functionality.
The primary membrane design challenge is to localize enzyme functionality at pore entrances and exits to enable directional flow of substrates/products over the enzyme active sites in an efficient manner.
The loss of function mutants I524K/Q/E were further subjected to suppressor analysis to examine if these mutants that were otherwise properly expressed and localized might be restored to functionality by compensatory mutations.
Strikingly, although FtsY requires membrane contact for functionality, cell fractionation studies have localized FtsY predominantly to the cytosolic fraction of Escherichia coli.
Localized solutions best solve local problems.
P2X7R of M-MDSCs was localized at the plasma membrane, coupled to increased functionality, upregulation of ARG-1, TGF- β1 and ROS.
In the AOM approach, functionality that addresses a pervasive access control concern is localized in an aspect.
First, numerous mammalian snoRNA pseudogenes were considered as genes, whereas most of them are localized outside of host genes and contain substitutions that question their functionality.
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CEO of Professional Science Editing for Scientists @ prosciediting.com