From the current set of experiments it is clear that binocular rivalry dominance is initially determined by low-level, spatially localized factors that are stable over periods of weeks.
We conclude that onset rivalry is independent of sustained rivalry and cannot be explained by local regions of monocular dominance or memory of past perceptual history, but rather reflects low-level, spatially localized factors that are stable over periods of weeks.
Similarly, Drosophila neuroblasts orient their spindle along the apicobasal axis through interactions at the cell cortex with apically localized factors [ 4].
When health events such as cancers are caused by exposure to geographically localized factors we might expect the exposure traces for the cases to cluster relative to the exposure traces that are generated for the controls.
Localized factors relating to differential limb growth may play a larger role in the distribution and density of osteocyte lacunae than previously thought, and are potentially biasing the interpretations of analyses based on single samplings of isolated specimens.
The development of a wound dressing that is capable of sustained, localized growth factor delivery would significantly improve treatment outcomes and accelerate clinical adoption.
Of note, LC were often present in clusters localized around Factor VIII+ blood vessels, suggesting the involvement of newly vascular-recruited precursor cells.
In conclusion, our experiments demonstrated that biomaterials composed of a biofunctionalized peptidic scaffold have many properties that are well-suited for the treatment of cutaneous wounds including wound coverage, functionalization with bioactive molecules, localized growth factor release and activation of wound repair.
The LPKY-motif in the endoplasmic reticulum localized transcription factor Spt23p was previously shown to interact with yeast Rsp5 (mammalian homolog NEDD4) (17).
Studies with ATPase deficient C. reinhardtii mutants which are not capable to assemble the thylakoid membrane localized coupling factor CF0 showed a progressive loss of PSII cores after several hours of medium light exposure [ 27].
Nrf2 is a cytoplasmically localized transcription factor that, in response to oxidative stress, translocates to the nucleus where it controls the expression and coordinated induction of a battery of genes critical for cellular protection and survival.
