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Bone regeneration can be accelerated by localized delivery of appropriate growth factors/biomolecules. Localized delivery can be achieved by a 2-level system: (i) incorporation of biomolecules within biodegradable particulate carriers (nanoparticles), and (ii) inclusion of such particulate carriers (nanoparticles) into suitable porous scaffolds.
There are a number of methods that can achieve localized delivery.
Thermosensitive liposomes have emerged as a viable strategy for localized delivery and triggered release of chemotherapy.
Kinoshita, M., McDannold, N., Jolesz, F. A. & Hynynen, K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption.
Strawberry confections may be a novel strategy for localized delivery and sustained release of strawberry bioactive compounds.
To address this limitation, we developed mmRNA-incorporated nanofibrillar scaffolds that could target spatially localized delivery and temporally controlled release of the mmRNA both in vitro and in vivo.
Localized delivery of drugs is an emerging field both with regards to drug delivery during disease as well as in tissue engineering.
All these results demonstrated the capability of this drug delivery device to achieve localized delivery of various compounds with well-defined temporal profiles.
As a proof-of-concept we have presented a simple device that allows localized delivery of therapeutic compounds.
The reduction in the size of the active sensor will ultimately require research on methods that enable localized delivery.
Methods: For localized delivery, Elvax 40P pellets containing p,p´-DDE were implanted into the mammary fat pads of prepubertal female mice.
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