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Localized background subtraction and merging of the intensity values from "high" and "low" scans was performed using the BASE software platform [ 49].
For DEcay SPECtroscopy (DESPEC) experiments with implanted radioactive beams a high resolution gamma tracking array is being designed at GSI. Exploiting the imaging capability of the array, a background suppression method is developed based on a separation of events originating from the target and from localized background sources.
It is, therefore, needed to adapt the operation of image change detection sub-module at each IN to become more sensitive when the localized background processes are active and less sensitive otherwise.
Then, a localized background normalization was performed to remove the differences in light intensity across each image [28].
Furthermore, we defined an abundance-window of 33% around a target protein as a localized background for calculating the statistical significance, by which we can evaluate the significant bias of a target protein-abundance compared to the abundance-distribution range of its neighbored proteins rather than to the abundance-distribution range of all identified proteins.
The median localized background slide signal for each clone was subtracted and each clone Cy5/Cy3 ratio subjected to print-tip loess normalization [ 14].
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Briefly this software, specifically developed for RPMA analysis, localizes the spots and subtracts the local background, calculating pixel intensity for each spot.
Localized enrichments of sequence tags are identified based on a binomial distribution model computed against a local background model surrounding each tag.
The R = 20 ROIs localized in the background were randomly chosen, in such a way that they were separated by at least two voxels from each other and at least three voxels from the phantom border.
In this paper, we will assume an acoustic scenario with a single target source, which is assumed to be a localized source, and background noise, which is assumed to be isotropic.
To address these issues, we have developed a hyperspectral-imaging microarray scanner [ 18] that allows the simultaneous quantification of all fluorescent species, including the spot-localized background leading to a significant improvement in the accuracy of microarray data.
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