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The first system is mediated by MGD1 and DGD1: it is localized at least partially in the inner envelope membrane of chloroplasts and is in charge of the bulk synthesis of the galactolipids MGDG and DGDG.
Its most successful candidates are on the far right of the Republican Party (localized at least: Scott Brown is no Rand Paul, but he is the Right of Massachusetts).
This suggested that ARTD10 is localized at least in part in the cell nucleus.
Renal K+ excretion is determined not only by active K+ secretion localized largely to the distal tubule and the cortical collecting tubule, but also by active K+ absorption localized, at least in part, to the outer medullary collecting tubule.
Since APP, PS1 (a component of the γ-secretase complex) and BACE1 (the β-secretase) have been localized, at least in part, to AEL vesicles, the vesicles may be a site of amyloidogenic APP processing (Cataldo et al., 2004; Yu et al., 2005).
While many Nox/Duox enzymes are localized at least in part at the cell surface where they can release their reactive oxygen product into the extracellular milieu, Nox4 is localized within the cell where it is reportedly localized to internal membranes such as the endoplasmic reticulum, nuclear membrane, and mitochondria.
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Although they were not conceived to process simultaneously active sources, in the latter situation they often exhibit several peaks that can be exploited to localize at least the main source.
In order for Itch and LITAF to interact they must localize, at least transiently, within the same compartment of the cell.
Subcellular fractionation experiments suggested that this protein localizes at least in mitochondria.
Consistent with the Allen Brain and Human Protein Atlases (Supplementary Material, Fig. S16), we further showed that APMAP is expressed in the brain, and more specifically in neurons where it co-localizes at least partially with APP and γ-secretase (Fig. 2B).
Why the two adaptors localize, at least in part, to different compartments is not clear, but differences in the molecular makeup of the compartments (e.g., ARF concentration, phosphoinositide composition) probably contribute.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com