In this setting, it is standard to rely on correlations between genotyped variants ('tags') and those that are 'tagged' (not genotyped) to identify and localize associations.
As coverage (genotype/imputation density) of the typical association study becomes more complete, the need to rely on correlations between functional signatures will diminish and their power to assist in identifying and localizing associations is expected to increase.
The IL2RA gene has also been associated with type 1 diabetes (T1D) [12] [14] and localized the association region in two independent groups of SNPs, spanning overlapping regions of 14 and 40 Kb encompassing IL2RA intron 1 and the 5' regions of IL2RA and the RNA binding motif protein 17 (RBM17) genes.
However, at prometaphase, it is localized in association with the half-spindles of the mitotic apparatus.
By electron microscopy, HSC70 was found localized in association with the plasma and nuclear membranes, the endoplasmic reticulum, small vesicles and the nucleus (Figure 1C).
Our screen isolated Toll-8, a receptor that has been reported to provide spatially localized heterophilic associations within the ectoderm necessary for supporting germband elongation (Pare et al. 2014).
He has also been at the forefront of devising statistical and computational methods to localize genetic association signals to causal variants, and to interpret human genetic data in the context of functional information.
GS and SMAA were also co-localized in association to large vessels situated in the reticular part of the dermis (not shown).
Given the high correlation between markers across this region, we cannot unequivocally localize the association signal to any one gene.
High magnification CLSM images of the stigma at the same stage showed the fluorescence to localize in association with the stigmatic papillae present throughout the stigma surface.
We observed distinct Xist RNA foci localized in close association with the nuclear matrix protein scaffold attachment factor-A (SAF-A) both within and at the boundary zone of the collapsed ANC permeating the entire Barr body.
