Thus, in order to better understand whether and how DNA circles are recognized by the cell, and to shed light on how they interfere with cellular physiology, we investigated how accumulating DNA circles localize and whether they affect nuclear organization.
It would be interesting to determine whether MGATs can localize to lipid droplets in enterocytes and whether the localization of MGLL and MGAT on the lipid droplet surface can vary depending on the metabolic state of these cells.
The 5 ATIP protein exhibit distinct motifs in their amino-terminal portion that determine whether they localize to the cell membrane, the cytosol or the nucleus (ATIP1, ATIP3 and ATIP4 localize to the cytosol, nucleus and plasma membrane, respectively).
Previous theoretical models suggested that individual cells may gain and loose certain properties depending on whether they localize inside or outside a specific environment [22].
In the model of Roeder et al. [35], [36], [38] individual cells gain and loose stem cell properties depending on whether they localize inside or outside a specific niche environment, respectively.
These results show that TE1 interferes with trafficking of all these membrane proteins, regardless of whether they localize apically or basally or if they are non-polarized in the PM.
It will be interesting to localize Mei-217 to determine whether it, too, shows predominantly cytoplasmic localization.
Although an obvious question is whether apicomplexan parasites have canonical autophagy and whether ATG8 proteins localize in autophagic membranes, the answers have been quite controversial.
First of all, staining is dependent on whether the proteins localize to and are abundant in the compartment of interest as well as whether the specific caspases are activated.
To further probe this idea, we first sought to determine whether zfTPP1 could localize to telomeres in zebrafish.
