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While Rod and Mad2 are known to stream from kinetochores to the poles, BubR1 does not normally shed from kinetochores.[40] In addition, the normal kinetochore localization timing of Cdc20 and BubR1 is distinct from that of Mad2 and the RZZ complex.
Lack of kinetochore localization of Mad2 or Mad1 (the Mad2 kinetochore receptor, displaying identical kinetochore localization timing as Mad2) strongly correlates with checkpoint weakening or impairment.
These differences in the ROS-dependent responses seem to be due to different localization, timing and level of ROS production under different stimuli [ 4, 5].
By selecting a concept (e.g. acute abdominal pain) in the tree, displayed on the left of the screen, a data entry form is displayed on the right with the descriptors (e.g. localization, timing, course) of the selected concept as options for data entry (figure 2).
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In addition to the localization, the timing and duration of β-catenin expression are important for proper lung development.
Aurora-B (Aur-B), a paralogue of Aur-A, differs in localization and timing of activation during cell cycle from Aur-A, despite the ∼60% sequence identity between them.
In contrast to ADAM10 and ADAM17 lack of ADAM8 appears to have a relatively minor impact on T cell development, which was unexpected given that maturation of thymocytes is dependent on proper localization and timing of migration.
Follow-up experiments that will identify the causal SNP and study its effect on the primary protein structure, protein folding, alternative splicing or expression (level, localization and timing) will be essential to better understand the precise mechanism by which this SNP affects HIV-1 replication in MDM.
This model reproduces SCD found in MS patients and allows for precise lesion localization and timing.
The localization and timing of transcription suggests that the identified genes are involved in the mid-late phases of spermatogenesis.
Thus, the localization and timing of histone H3 Ser and Thr phosphorylation during mitosis differ between plants and animals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com