Exact(6)
Further studies of localization, specificity and expression patterns are needed in order to determine the function of this novel MIP subfamily.
Finally, we altered the crucial functional groups in the imidazolyl ring of C2 to estimate their contribution to the localization specificity and fluorescence properties of the compound.
This underlines the fact that Apoptin's nuclear localization specificity is imparted by the tNTS and can be conferred on heterologous proteins which are normally exclusively nuclear.
A specific hydrogen bonding interaction between the 2′-OH group in the appended phenyl ring and the –NH group attached to the imidazole ring was found to confer localization specificity to the complex.
In the past decade, a vast body of research has provided converging evidence that the key mechanism of the mode of action of the PP1c subunit resides in the presence of interacting regulators that direct the proper functions of this phosphatase (i.e. localization, specificity and the level of activity) [ 21- 23].
In contrast, the recessive allele e1-as possessed a nonsynonymous substitution in the putative nuclear localization signal, leading to reduced localization specificity of the E1 protein in nucleus and thereby reducing the ability of E1 to suppress expression of the GmFT genes [ 13].
Similar(54)
All the drugs tested induced an increase of surface roughness, to an extent correlated with the localization and specificity of the target.
Other features of OsPYLs such as expression pattern, subcellular localization, interaction specificity with OsPP2C, and biological function, have not been examined.
Incubation with fluorescent 50 nm microspheres (Fluoresbrite® Yellow Green Microspheres Additional file 3) and subsequent fluorescence analysis indicates devices localization, selectivity, specificity, and absence of signal from the background (noise) (Fig. 1f).
For example, the other subunits could control parkin stability, subcellular localization, substrate specificity or ubiquitin ligase activity (including the preference of parkin for mono- vs polyubiquitination).
Different classes of nucleic acid-sensing molecules have been identified; these molecules are classified on the basis of cellular localization, target specificity, and downstream signaling pathway.
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