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Confirming the above data, the inhibition of PKC θ by Rottlerin in a pre-TCR-competent context resulted in a change of Numb localization, promoting nuclear Numb accumulation.
T βRIII suppresses cancer progression by stabilizing the ECM and by accumulating α5 β1 integrin in its activated state; therefore, T βRIII decreased expression could disrupt ECM structure and influence α5 integrin localization, promoting cancer progression by enhancing cell motility and invasion [ 99].
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The magnitude of promoter activity was significantly increased in the presence of TTP, consistent with observed p53 protein stabilization and nuclear localization promoted by TTP.
Active MEKK1 induces NF-κB nuclear localization by promoting the degradation of IκB [ 32].
Aub participates in their localization by promoting their decay in the somatic part of the embryo.
Akt induces Yap phosphorylation at Ser-127, resulting in Yap cytosolic localization via promoting Yap binding with 14-3-3 14-3-3 14-3-3 inactivation of Yap [ 30].
The same RNA localization signal can promote localization and the protein machinery that recognizes this "zipcode" signal is widely expressed (Bullock, 2001; Jambor, 2014).
Wang, T., Hamilla, S., Cam, M., Aranda-Espinoza, H. & Mili, S. Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration.
The greater mobility of Mu in the active site and larger opening of the active site appear to disrupt water localization and promote its mobility.
Similarly, latrunculin A treatment (which produces monomeric actin), but not swinholide A (which produces dimeric actin), sequestered megakaryoblastic leukemia 1 (MKL1) nuclear localization and promoted PPARγ expression.
The Ulp1 localization domain promotes interaction with karyopherins, which are soluble proteins that mediate transport across the NE and help localize Ulp1 to the nucleoplasmic side of the NPC.
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