For each pattern, there is a set of fixed parameters that define the nature of the localization pattern.
Note that βH-Spec was highly enriched at the fusogenic synapse, whereas β-Spec exhibited a general cortical localization pattern.
Interestingly, the intra-nuclear localization pattern of CEP192 transcripts was not among the patterns used for simulation.
As an example, MreB localization pattern is growth-dependent, which drives changes of cell shape at different growth phases.
While the degree of uptake is increased in the overexpressing cells, the cellular localization pattern is observed to be the same.
For instance, it can show the existence of small sub-groups of cells with a very specific localization pattern, or mixtures of different patterns.
We found that cells from different genes with the same or similar manually annotated localization pattern showed an important overlap in the t-SNE plot.
This localization pattern of activated Akt has been demonstrated previously29,30, and it is known to be required for fully mediating the effect of the growth factor signaling31.
Rho has a dynamic localization pattern throughout ovarian and embryonic development.
The subcellular distribution of tagged human VIP1 is indicative of a cytoplasmic non-membrane localization pattern.
As expected, complementation of the ga5dh gene faithfully restored a normal FtsZ localization pattern (Fig. 7).
