Sentence examples for localization of the compounds from inspiring English sources

These in vitro cell culture models have been extremely valuable in determining the toxic effects of novel compounds on cellular functions and in studying the mechanisms of barrier formation, the uptake and localization of the compounds within the cell, as well as the effects on cell cell interactions.

(539) Studies of sphingolipid metabolism in vivo are complicated by the loss of information about histological localization of the compounds of interest after the tissues have been homogenized for extraction and analysis.

Computer-assisted SAR analysis of compound B revealed that its furan-associated bicyclic nucleus harbors the antitubulin activity of the compound whereas its C2 side chain is important for overall activity, possibly by affecting the localization of the compound to the tubulin pocket.

Important objectives of further studies of ML 3000 are definition of the mechanisms of H,K-ATPase inhibition and AGS cell IL-8 secretory inhibition, an assessment of ML 3000 in vivo acid inhibitory efficacy in a rat model, and whole body distribution and localization of the compound.

However, given the large amount of liquid hydrocarbon in the extracellular matrix and that we infrequently see dead cells of B. braunii Showa within a colony that is rapidly accumulating extracellular hydrocarbons, the contribution of cell death to the extracellular localization of these compounds may only be limited.

More recently, the almost exclusive localization of this compound to within the cytoplasm of the glial cells located within the axonal fascicles of the nerve has been confirmed [ 29].

To improve resolution to gain a further insight into the subcellular localization of edelfosine, we used the novel Et-BDP-ET and Yn-BDP-ET analogs, which allowed us to visualize the subcellular localization of the fluorescent compounds in HeLa cells through confocal microscopy, as the fluorescent signal was more stable.

Based on our three-dimensional homology model of the TSHR, the localization of both compounds within the binding pocket in the transmembrane domain was predicted and shown to be very similar, but differs in a shifted orientation of the molecules.

The accumulation and vacuolar localization of the yellow fluorescent compounds was not affected by the treatment with BFA or monensin (not shown).

The immunocytochemical localization of neuroactive compounds provides information on the anatomy and certain biochemical pathways expressed in a particular neuron.

The localization of such compounds in gall tissues is considered a defensive chemical strategy of gall inducers against natural enemies (Bronner 1992) for their unpalatability.