In summary, findings presented here indicate that the FopC protein of F. novicida is a virulence determinant and functions to maintain membrane integrity and the proper localization of factors such as AcpA which may be one of several F. novicida bacterial components involved in the dephosphorylation of STAT1 to inhibit IFN-γ-mediated signaling.
WRAP53 β clearly plays a central role in the maintenance and localization of factors involved in splicing and telomere elongation to the Cajal body and was also recently shown to control the repair of DNA double-strand breaks by both the HR and NHEJ pathways through targeting the critical ubiquitin ligase RNF8 to these lesions.
Fager, AM, Machlus, KR, Ezban, M, and Hoffman, M. "Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity". Journal of Thrombosis and Haemostasis : Jth 16, no. 9 (September 2018): 1817-1829.
We propose that the adherens junction formed between the niche component (hub cells) and stem cells (GSCs) serves as a platform for multiple functions essential for stem cells: 1) maintenance of stem cells within the niche by physically anchoring the stem cells, 2) polarization of stem cells with respect to the niche, and 3) localization of factor(s) required for monitoring stem cell polarity.
Immunohistochemical localization of factor VIII related antigen on endothelial cells was determined using the polyclonal rabbit antihuman von Willebrand factor purchased from Dako Cytomation (Glostrup, Denmark), using the manufacturer's recommended staining protocol.
Immunohistochemical localization of factor VIII related antigen on endothelial cells was determined using the polyclonal rabbit anti-human Von Willebrand Factor (Dako Cytomation, Carpinteria, CA, USA), using the manufacturers' recommended staining protocol.
Subnuclear localization of transcription factors can give clues to the type of gene regulation.
Cytoskeleton modifications leading to altered localization of nuclear factors may result in loss- or gain-of-function of such factors, which affects the cell cycle and cell development.
When mitochrondria are functional and sufficient nitrogen is available, the transcription factors are cytoplasmic; disruption of mitochrondrial function or nitrogen depletion results in nuclear localization of the factors and subsequent transcriptional activation of target genes.
In addition, fabrication of tissue engineered blood vessels benefitted from progress in biomaterials technologies as well as controlled release and localization of growth factors for vascular development.
These events were probably triggered by the combination of chemical (scaffold composition and surface chemistry) and structural (pore size and interconnected porosity) cues that are known to favor the localization of growth factors with anti-inflammatory potential38,39, thus promoting cells' infiltration and retention throughout the scaffold thickness, respectively33.
