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Additionally, the absence of plastin 1 could affect the transport or localization of components of the mechanotransduction machinery.
It is intriguing that both share the ability to regulate activation and subcellular localization of components of the MAP kinase (ERK1,2) cascade [ 48, 61, 62].
We thus reassessed these relationships by comparing the localization of components of the different polarity complexes in baz EH747, baz XR11, baz and baz lateral FE clones by immunostaining analysis.
To investigate whether the puffy X phenotype in Top2 mutant males resulted from altered dosage compensation, we examined X chromosome localization of components of the MSL complex in Top2 / Top2 Df9043 and Top2 / Top2 Df9043 male larvae.
Overall, this report presents some exciting new findings that are very timely in view of (i) extensive ChIPseq data in the literature demonstrating the localization of components of the Pol III transcription machinery adjacent to Pol II-transcribed genes and (ii) the widespread localization of SINE elements (of unknown function) in the human genome and near promoters.
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This furthered SAIC's objective of developing design capabilities, thereby promoting good partner relations, and facilitating the localization of component sourcing and product development.
What is clear, however, is that H. pylori preferentially adhere to gastric epithelial cells in close proximity to the apical junctional complex [ 27, 40], and can alter localization of component proteins that constitute apical-junctional complexes [ 27, 41- 43].
However, in this case, the co-localization of components (e.g. protein domains) can also lead to unwanted context effects.
Further profiling, determination of the timing of appearance of molecular components, and careful analysis of the localization of these components is required for the accurate construction and assignment of interactions to appropriate cell types or CNS regions (Fig. 4B).
Asymmetric localization of subcellular components can be achieved by regulating the distribution of these components and the mitotic spindle relative to one another so that the two daughter cells terminate cytokinesis with distinct sets of these factors [ 2,3].
Given the abnormal localization of nucleolar components during mitosis, it is no surprise that the segregation of these components is perturbed in mitosis.
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