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The key findings are: (1) transcription spatially determines the localization of axis proteins along chromosomes due to their association with cohesin.
This oocyte ventralization defect suggests that localization of axis determining factors requires sticky kinase and Fmrp function and/or that Cbl overexpression in the ovary can lead to polarity defects.
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This polarized distribution of PAR proteins induces the formation of an anterior-posterior gradient of microtubules that directs the localization of the axis determining transcripts to define the AP axis of the future embryo (Bastock and St Johnston, 2008).
DOI: http://dx.doi.org/10.7554/eLife.07424.003 10.7554/eLiFigure24.004 Figure 1 figure supplement 1. Genome-wide localization of meiotic axis proteins and cohesin.
If cohesin plays a role in the transcription-dependent localization of meiotic axis proteins, these distribution patterns should no longer be apparent when the cohesin ring is disrupted.
Using the same localization of short-axis slices on corresponding gadolinium-enhanced images 12 min after contrast injection (Fig. 2b) and the two perfusion slices (Fig. 2c) regional myocardial blood flow in late-MVO region, gadolinium-hyperenhanced area without MVO, border zone and remote myocardium was determined.
When considering the deformation mode of the specimens during the cyclic loading, a permanent plastic valgus malrotation of the tibial head occurred which caused a valgus deformation of the knee, consequently altering the localization of the mechanical axis and the primary performed correction.
I compare phenotypic differences in nematode embryogenesis in two basic cell biological processes, the cell cycle and the localization of the first division axis.
The pinhole was opened slightly (1.4 µm optical slice) to account for the slightly higher Z-axis localization of IQGAP at invadopodia.
It also helps in better localization of these impulses on time axis.
The results image the basin-scale symmetry, the perennial localization of the NW SE-oriented basiNW SE-orientedlt movements due to tectonics and/or basinl, axisthe transaltse segmovements of the Polish Basin.
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